Pep Guardiola and Man City face Everton at Goodison Park on Sunday, little more than 72 hours before they take on Real Madrid in the second leg of their Champions League semi-final.
Real are in La Liga action against Getafe on Saturday and therefore have an extra day’s rest.
“It is what it is,” said Pep Guardiola.
He said one of the issues that meant their trip to Everton was being played on Sunday was that Liverpool is hosting the Eurovision Song Contest on Saturday.
The Spaniard added: “In the end, we can’t play Saturday because of Eurovision or something like that in Liverpool and we don’t have enough bodies to handle two important events sometimes.
“I can’t understand it but I’m not going to fight it any more.
“OK, you have to adapt. What can I do? We’d prefer to play Saturday to be able to prepare but it is what it is.
“I’m pretty sure the Premier League want to help the teams. I don’t think they make it uncomfortable.”
Sunday’s trip to Merseyside is a crucial match at both ends of the Premier League, with City looking to maintain their lead over Arsenal at the top and 17th-placed Everton battling to avoid relegation.
City drew 1-1 with Real in the first leg of their semi-final on Tuesday and while a place in the Champions League final is at stake next week, Guardiola says the focus is firmly on facing Sean Dyche’s Toffees.
“My thought is just Everton – no more than that,” he said.
“It’s 11 months working for the Premier League. We don’t have much time to [prepare for] Madrid because we play Sunday – thank you so much – but it’s a real, real priority, Goodison Park.”
After Everton, City’s last league fixtures will see them take on Chelsea at home and Brighton away before ending the season at their west London neighbours Brentford.
Though City have a game in hand, Arsenal are just one point behind Guardiola’s side at the top of the table.
Pep Guardiola believes the Gunners will “definitely” win their remaining matches – against Brighton, Nottingham Forest and Wolves – but the City boss is adamant his team must not rely on others’ results.
“There are four games left in the Premier League and it’s really important to be there and keep our destiny in our hands,” he said.