Portugal vs Uruguay on Monday night in a rematch of the 2018 World Cup knockout tie between the pair.
Cristiano Ronaldo become the first man to score in five World Cups as Portugal overcame Ghana in their first game, although they will surely face a more difficult task against Uruguay.
As has been the case since their Euro 2016 win, Fernando Santos' side haven't proven convincing and were even somewhat fortunate to come through the Ghana game with three points.
Uruguay, meanwhile, were hardly the most progressive during their draw with South Korea but certainly have the quality in attack capable of hurting Portugal.
Nuno Mendes had been struggling with muscular discomfort which kept him out of Portugal's opener against Ghana.
Otavio joined the PSG wingback in the recovery room after sustaining a hamstring problem during the match.
Ronald Araujo's World Cup looked to be over when he was forced into thigh surgery at the end of September.
Nevertheless, Diego Alonso selected the Barcelona centre-back who is expected to only be available from the knockout stage onwards – if Uruguay make it that far.
Portugal and Uruguay are on an even footing as far as the head-to-head record is concerned and have won one game apiece out of a total of three matches played between the two teams.
The previous meeting between the two teams took place in the 2018 World Cup in Russia and ended in a 2-1 victory for Uruguay, resulting in Portugal's elimination from the competition.
Uruguay have won four of their last five matches against European nations in the FIFA World Cup but did lose their previous such encounter against France.
Portugal have lost only one of their last nine matches against South American opponents in all competitions, with their previous such victory coming against Argentina in 2014.
Portugal Starting 11 (4-3-3): Costa; Cancelo, Pereira, Dias, Guerreiro; Bernardo, Neves, Carvalho; Fernandes, Ronaldo, Felix.
Bench: Patricio, Sa, Andre Silva, Dalot, Pepe, Palhinha, Vitinha, Mario, Nunes, Horta, Ramos, Antonio Silva, Leao.
Uruguay Starting 11 (4-3-3): Rochet; Caceres, Godin, Gimenez, Oliveira; Valverde, Bentancur, Vecino; Pellistri, Suarez, Nunez.
Bench: Muslera, Sosa, Coates, Vina, Varela, Rodriguez, Torreira, Ugarte, De la Cruz, Arrascaeta, Torres, Canobbio, Gomez, Cavani.
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