Casemiro and Zirkzee on for Ugarte and Sesko.
Sevilla sent the Red Devils crashing out of the Europa League thanks to an emphatic 3-0 win in during Sevilla vs Man United on Thursday's quarterfinal second leg at the Ramon Sanchez-Pizjuan to seal a 5-2 aggregate triumph.
Sevilla, who had been 2-0 down before a late fight back to level last week's first leg, stunned the Premier League giants, who were again masters of their own downfall in an error-strewn performance.
Youssef En-Nesyri capitalised on a Harry Maguire mistake to go in front in the tie after eight minutes before Loic Bade headed in a corner two minutes into the second half.
Completing United's misery, David de Gea badly miscontrolled a long ball as he ran out of his box to gift an open goal for En-Nesyri to put the result beyond doubt with nine minutes remaining.
Despite a poor domestic season that has led them to change manager twice, the win continues Sevilla's remarkable history in the competition, having won six Europa League titles and four in the last nine seasons. They will now face Juventus in the semifinals.
Manchester United face Brighton in the FA Cup semi-finals on Sunday; Sevilla host Villarreal on Sunday in La Liga.
Sevilla vs Man United: Match Summary
Inside the opening ten minutes of action, however, the tone for the evening - a less than positive one from a United perspective - was set.
This came upon a calamitous mix-up between David de Gea and Harry Maguire opening the door for Youssef En-Nesyri to put Sevilla in front both on the night, and in the tie.
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The Spaniards continued to dominate as proceedings wore on, with only the narrowest of offside calls having prevented Lucas Ocampos from making it two.
Just minutes into the 2nd-half of Sevilla vs Man United, however, Sevilla did double their advantage.
Loic Bade proved the man on target this time round, nodding a looping header beyond David de Gea and in at the far post.
And there was still time for José Mendilibar's men to add a third, as yet another David de Gea mistake - highlighting the Spaniard's struggles with the ball at his feet once again - allowed En-Nesyri to slot home into an empty net.
This, in turn, is how things remained through the full-time whistle in Andalusia, as Sevilla sent a lacklustre Manchester United packing from the Europa League, to book their spot in the competition's semi-finals.
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Perfect game for United. Although Brighton fought back hard, and it was a nervy late few minutes for United, they would be enjoying this win.
Mainoo with a long pass, and Mbuemo finds the back of the net with a clinical finish.
From the James Milne corner, Kostulas heads the ball inside the goal.
MAN, WHAT A GOAL!
3-0!
Suddenly, the luck is in United's favour.
Cunha scores his first-ever Manchester United goal, and what a way to score that. 


Once again, it is Harry Maguire who scores a late winner for United.
WHO ELSE?
In: Ekitike, Wirtz, Jones
For the second time, the Dutch striker hits the post.
End of an exciting first half. Chances for both teams, but it is Manchester United who are leading by 1-0 after that early goal by Bryan Mbuemo.
Bryan Mbeumo scores early for Manchester United. 

From the corner, Chelsea scores.
The continuous rain has left water on the pitch, and the ball is not moving smoothly.
Casemiro makes it 2-0 for United.
Andrey Santos replaces Palmer. 



HE IS BACK! HE IS BACK! HE IS BACK!
Donnarumma with a big save, diving to his right.
Inevitable!
City head into the tunnel with a 1-0 lead, and a well-deserved lead, you have to say.
Sesko tries to lob a ball from inside the box, but the Italian had came out early to make the save.
Phil Foden, for the seventh time in his career, scores a Manchester Derby goal for the City.




Dorgu made a great run on the left and then smashed the ball on the side net. However, he was offside.